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Submit ReviewPD 90780
说明： Inhibits NGF binding to p75NTR
化学名： 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for PD 90780
PD 90780 is a a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
技术数据 for PD 90780
| 分子量 | 362.34 |
| 公式 | C19H14N4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 77422-99-2 |
| PubChem ID | 9885305 |
| InChI Key | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=CC=C4)NC1=CC=C3C(C(N2C(N3C)=CC(C(O)=O)=N2)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 90780
参考文献 for PD 90780
参考文献是支持产品生物活性的出版物。
Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505 PMID: 15051797
Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266 PMID: 23103525
Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63 PMID: 18289033
关键词: PD 90780, PD 90780 supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, receptor, TrkA, neuroprotective, nerve, growth, factors, Trk, Receptors, 5101, Tocris Bioscience
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