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PDD 00017238

Cat. No. 7007 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity and potent PARG inhibitor
化学名： 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PDD 00017238

PDD 00017238 is a high affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM).

Negative control PDD 00031705 (Cat. No. 7009) also available.

许可信息

Sold under license from Cancer Research Technology Ltd (Ximbio).

技术数据 for PDD 00017238

分子量 476.59
公式 C19H20N6O3S3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1952247-05-0
PubChem ID 121415983
InChI Key FLUZEVGWXJVSPX-UHFFFAOYSA-N
Smiles CC1=NC(C)=C(S1)CN2C(N(C3=CC(S(=O)(NC4(CC4)C)=O)=CC=C23)C5=NC=NS5)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PDD 00017238

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 0.95 2

制备储备液 for PDD 00017238

以下数据基于产品分子量 476.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.02 mM 104.91 mL 524.56 mL 1049.12 mL
0.1 mM 20.98 mL 104.91 mL 209.82 mL
0.2 mM 10.49 mL 52.46 mL 104.91 mL
1 mM 2.1 mL 10.49 mL 20.98 mL

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参考文献 for PDD 00017238

参考文献是支持产品生物活性的出版物。

James et al (2016) First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 11 3179 PMID: 27689388

If you know of a relevant reference for PDD 00017238, please let us know.

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关键词: PDD 00017238, PDD 00017238 supplier, PDD00017238, potent, high, affinity, poly, ADP, ribose, glycohydrolase, PARG, inhibitors, inhibits, Poly(ADP)-ribose, Glycohydrolase, 7007, Tocris Bioscience

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