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PDEδ ATTEC 12C

Cat. No. 8824 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PDEδ autophagy-tethering compound (ATTEC) Degrader
化学名： N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PDEδ ATTEC 12C

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

技术数据 for PDEδ ATTEC 12C

分子量 999.54
公式 C41H42Br2IN7O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key BYPQUTISFKWFMK-DXJNIWACSA-N
Smiles BrC1=CC(/C=C2C(C=C(I)C=C3)=C3NC/2=O)=CC(Br)=C1OCC(NCCCCCCNC(CCCN4C(C5=NN(C6=CC=C(C)C=C6)C(C)=C5C(C)=N4)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PDEδ ATTEC 12C

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.99 20

制备储备液 for PDEδ ATTEC 12C

以下数据基于产品分子量 999.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 5 mL 25.01 mL 50.02 mL
1 mM 1 mL 5 mL 10 mL
2 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.1 mL 0.5 mL 1 mL

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产品说明书 for PDEδ ATTEC 12C

分析证书/产品说明书
化学品安全技术说明书

参考文献 for PDEδ ATTEC 12C

参考文献是支持产品生物活性的出版物。

Bao et al (2024) Discovery of novel PDEδ autophagic degraders: a case study of autophagy-tethering compound (ATTEC). ACS Med.Chem.Lett. 15 29 PMID: 38229750

If you know of a relevant reference for PDEδ ATTEC 12C, please let us know.

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关键词: PDEdelta ATTEC 12C, PDEdelta ATTEC 12C supplier, pdedelta, attec, 12c, degrader, degraders, degrades, autophagy, autophagic, tethering, compound, PDEd, PDE, KRAS, pancreatic, cancer, cell, lines, apoptosis, antiproliferative, Other, Degraders, 8824, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia