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PE 22-28

Cat. No. 7868 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent inhibitor of TREK-1 channels
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PE 22-28

PE 22-28 is a potent inhibitor of potassium channel subfamily K member 2/TREK-1 (IC50 = 0.12 nM). In rodent models of ischemia PE 22-28 reduces apoptotic death of β cells, increases hippocampal neurogenesis, and reduces stroke-induced motor and cognitive defects.

技术数据 for PE 22-28

分子量 773.89
公式 C35H55N11O9
序列 GVSWGLR
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1801959-12-5
PubChem ID 165437303
InChI Key CMNBQRXBBJQIOA-YIHYGEMESA-N
Smiles O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CN

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PE 22-28

溶解性 Soluble to 2 mg/ml in water

参考文献 for PE 22-28

参考文献是支持产品生物活性的出版物。

Daziano et al (2021) Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol.Res. 167 105539 PMID: 33737242

Pietri et al (2019) First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology 158 107715 PMID: 31325429

If you know of a relevant reference for PE 22-28, please let us know.

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关键词: PE 22-28, PE 22-28 supplier, PE2228, TREK1, TREK, inhibitor, inhibits, inhibitors, potent, ischemia, beta, cells, neurogenesis, neuroprotective, potassium, channel, subfamily, K, member, 2, Two-P, Potassium, Channels, 7868, Tocris Bioscience

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