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Submit ReviewPEAQX tetrasodium salt
说明： Potent and GluN2A-selective NMDA antagonist
化学名： [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
纯度： ≥98% (HPLC)
生物活性 for PEAQX tetrasodium salt
PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for PEAQX tetrasodium salt
| 分子量 | 542.14 |
| 公式 | C17H13BrN3Na4O5P |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 76900415 |
| InChI Key | QBVOZIDKUFSQIL-LPOFVUTESA-J |
| Smiles | C[C@@H](C3=CC=C(Br)C=C3)NC(P([O-])([O-])=O)C1=C2C(N=C([O-])C([O-])=N2)=CC=C1.[Na+].[Na+].[Na+].[Na+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PEAQX tetrasodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 5.42 | 10 温和加热 |
制备储备液 for PEAQX tetrasodium salt
以下数据基于产品分子量 542.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.45 mL | 92.23 mL | 184.45 mL |
| 0.5 mM | 3.69 mL | 18.45 mL | 36.89 mL |
| 1 mM | 1.84 mL | 9.22 mL | 18.45 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
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产品说明书 for PEAQX tetrasodium salt
参考文献 for PEAQX tetrasodium salt
参考文献是支持产品生物活性的出版物。
Auberson et al (2002) 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg.Med.Chem.Lett. 12 1099 PMID: 11909726
If you know of a relevant reference for PEAQX tetrasodium salt, please let us know.
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关键词: PEAQX tetrasodium salt, PEAQX tetrasodium salt supplier, NVP-AAM, 077, anticonvulsants, potent, selective, NMDA, subtype, antagonists, antagonism, 459836-30-7, 2102348-87-6, Receptors, 5018, Tocris Bioscience
2 篇 PEAQX tetrasodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PEAQX tetrasodium salt 的部分引用包括：
Pavel et al (2021) Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats. Pharmaceutics 13 PMID: 33808912
Eckart D et al (2022) Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell Calcium 106 102623 PMID: 35853264
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