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Submit ReviewPentamidine isethionate
说明： NMDA antagonist: antimicrobial
化学名： 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
纯度： ≥99% (HPLC)
生物活性 for Pentamidine isethionate
Pentamidine isethionate is an antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
技术数据 for Pentamidine isethionate
| 分子量 | 592.68 |
| 公式 | C19H24N4O2.2C2H6O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 140-64-7 |
| PubChem ID | 8813 |
| InChI Key | YBVNFKZSMZGRAD-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N.OCCS(=O)(O)=O.OCCS(=O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pentamidine isethionate
参考文献 for Pentamidine isethionate
参考文献是支持产品生物活性的出版物。
Reynolds and Aizeman (1992) Pentamidine is an N-MthD.-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970 PMID: 1532027
Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299 PMID: 7542607
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关键词: Pentamidine isethionate, Pentamidine isethionate supplier, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, oxide, Synthases, Miscellaneous, Compounds, 3277, Tocris Bioscience
1 篇 Pentamidine isethionate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pentamidine isethionate 的部分引用包括：
Capoccia et al (2015) S100B-p53 disengagement by pentam. promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncol Lett 9 2864 PMID: 26137161
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