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Pentostatin

Cat. No. 2033 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Adenosine deaminase inhibitor
别名： Deoxycoformycin
化学名： (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pentostatin

Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.

技术数据 for Pentostatin

分子量 268.27
公式 C11H16N4O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 53910-25-1
PubChem ID 439693
InChI Key FPVKHBSQESCIEP-JQCXWYLXSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pentostatin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 26.83 100
DMSO 20.12 75

制备储备液 for Pentostatin

以下数据基于产品分子量 268.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Pentostatin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Pentostatin

参考文献是支持产品生物活性的出版物。

Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666

Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429

If you know of a relevant reference for Pentostatin, please let us know.

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关键词: Pentostatin, Pentostatin supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Deoxycoformycin, Deaminases, 2033, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 篇 Pentostatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pentostatin 的部分引用包括：

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697

Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986

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