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Deaminases

Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia. They are usually named after their substrate; two well known members of this group are adenosine deaminase and cytidine deaminase.

Products
Background
Gene Data

Deaminase Inhibitors
Cat. No. Product Name / Activity
6868 8-Azaadenosine
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
4488 1-Deazaadenosine
Adenosine deaminase inhibitor
1261 EHNA hydrochloride
Adenosine deaminase inhibitor
2033 Pentostatin
Adenosine deaminase inhibitor
2293 Zebularine
Cytidine deaminase and DNA methyltransferase inhibitor

Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia. They are usually named after their substrate and two well known members of this group are adenosine deaminase (E.C. 3.5.4.4) and cytidine deaminase (E.C. 3.5.4.5).

Adenosine deaminases (ADA) irreversibly convert adenosine into inosine by the removal of an amino group and they are necessary for the breakdown of food and turnover of nucleic acids. Cytidine deaminases convert cytosine and deoxycytosine to uridine and deoxyuridine respectively, and are involved in maintaining the cellular pyrimidine pool. Other members of this group include guanine deaminase (GDA) (converts guanine to xanthine), dCMP deaminase (DCTD) (involved in cytosine metabolism) and porphobilinogen deaminase (PBGD) (involved in heme biosynthesis).

External sources of pharmacological information for Deaminases :

    Deaminase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ADA Human ADA NM_000022 P00813
    Mouse Ada NM_007398 P03958
    Rat Ada NM_130399 Q920P6
    CDA Human CDA NM_001785 P32320
    Mouse Cda NM_028176 P56389
    Rat Cda NM_001108688 XP_342956
    GDA Human GDA NM_004293 Q9Y2T3
    Mouse Gda NM_010266 Q9R111
    Rat Gda NM_031776 P36577
    DCTD Human DCTD NM_001012732 P32321
    Mouse Dctd NM_178788 Q8K2D6
    Rat Dctd NM_001013882 Q5M9G0
    PBGD Human HMBS NM_000190 P08397
    Mouse Hmbs NM_013551 P22907
    Rat Hmbs NM_013168 Q9R2B9