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Submit ReviewPentoxifylline
说明： PDE inhibitor
别名： PTX
化学名： 3,7-Dimethyl-1-(5-oxohexyl)xanthine
纯度： ≥99% (HPLC)
生物活性 for Pentoxifylline
Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.
技术数据 for Pentoxifylline
| 分子量 | 278.31 |
| 公式 | C13H18N4O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 6493-05-6 |
| PubChem ID | 4740 |
| InChI Key | BYPFEZZEUUWMEJ-UHFFFAOYSA-N |
| Smiles | O=C(C(N(C)C=N2)=C2N1C)N(CCCCC(C)=O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pentoxifylline
参考文献 for Pentoxifylline
参考文献是支持产品生物活性的出版物。
Monshouwer et al (1996) Differential effect of pentoxify. on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195 PMID: 8937426
Vale et al (2004) Antihyperalgesic effect of pentoxify. on experimental inflammatory pain. Br.J.Pharmacol. 143 833 PMID: 15520047
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关键词: Pentoxifylline, Pentoxifylline supplier, PDE, inhibitors, inhibits, Phosphodiesterases, PTX, 3056, Tocris Bioscience
18 篇 Pentoxifylline 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pentoxifylline 的部分引用包括：
Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286 PMID: 25850004
Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71 PMID: 26198357
Zhang and Sun (2011) Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Neuroscience 71 221 PMID: 20936660
Wang et al (2017) Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest 127 1978 PMID: 28414301
Park (2015) Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. J Neurosci 2015 275126 PMID: 26617436
Feng et al (2015) Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. J Neurophysiol 113 2618 PMID: 25652923
Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131 PMID: 19339608
Kumar and Foster (2013) Linking redox regulation of NMDAR synaptic function to cognitive decline during aging. J Neurosci 33 15710 PMID: 24089479
Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID: 20519319
Bailes et al (2012) Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. Dev Neurobiol 7 e30774 PMID: 22292038
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Toxicol Sci 5 10468 PMID: 26020477
Thueson et al (2015) In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells. Sci Rep 143 418 PMID: 25433234
Wang et al (2015) β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure. Mediators Inflamm 5 7681 PMID: 25567365
Guidi et al (2015) Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors. PLoS One 35 3966 PMID: 25740525
Simonson et al (2015) Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Mol Biol Cell 172 515 PMID: 24641310
Zhang et al (2011) Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex. Br J Pharmacol 174 45931 PMID: 21115101
Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031 PMID: 15257286
Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047 PMID: 17178407
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