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说明： Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude
生物活性 for pep2-SVKI
pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).
Control Peptide also available.
技术数据 for pep2-SVKI
| 分子量 | 1284.47 |
| 公式 | C60H93N13O18 |
| 序列 | YNVYGIESVKI |
| 储存 | Desiccate at -20°C |
| CAS Number | 328944-75-8 |
| PubChem ID | 90479807 |
| InChI Key | YWTNLHXVGSIPEM-YDSVATBTSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for pep2-SVKI
参考文献 for pep2-SVKI
参考文献是支持产品生物活性的出版物。
Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3 PMID: 12941441
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873 PMID: 11163273
Kim et al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972 PMID: 10526335
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关键词: pep2-SVKI, pep2-SVKI supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, GRIP, ABP, PICK1, Increases, AMPA, current, amplitude, Glutamate, Receptors, iGlur, Ionotropic, GluA2, 1597, Tocris Bioscience
4 篇 pep2-SVKI 的引用文献
引用文献是使用了 Tocris 产品的出版物。 pep2-SVKI 的部分引用包括：
Dickinson et al (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain 2 18 PMID: 19534762
Grey and Burrell (2010) Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol 103 2737 PMID: 20457859
McElligott et al (2010) Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. J Neurosci 107 2271 PMID: 20133871
Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288
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