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Submit ReviewPeptide derived from the heparin-binding domain in the B1 chain of laminin. Binds to heparin, promotes cell adhesion, and inhibits the migration towards, and adhesion of metastatic fibrosarcoma cells to laminin.
分子量 | 2427.9 |
公式 | C110H175N31O27S2 |
序列 | RYVVLPRPVCFEKGMNYTVR |
储存 | Desiccate at -20°C |
CAS Number | 117609-40-2 |
Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
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Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Charonis et al (1988) A novel synthetic peptide from the B1 chanin of laminin with heparin-binding and cell adhesion-promoting activities. J.Cell Biol. 107 1253 PMID: 3417782
Schuger et al (1996) Laminin and heparan sulfate proteoglycan mediate epithelial cell polarization in organotypic cultures of embryonic lung cells: evidence implicating involvement of the inner globular region of laminin β 1 chain and the heparan sulfate groups of hepara Dev.Biol. 179 264 PMID: 8873769
Skubitz et al (1990) Definition of a sequence, RYVVLPR, within laminin peptide F-9 that mediates metastatic fibrosarcoma cell adhesion and spreading. Cancer Res. 50 7612 PMID: 2253210
关键词: Peptide F9, Peptide F9 supplier, inhibitors, inhibits, laminin-mediated, cell, adhesion, migration, Adhesion, Molecules, heparin, PeptideF9, Cell, 1903, Tocris Bioscience
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