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Submit ReviewPF 06726304 acetate
说明： Highly potent and SAM-competitive EZH2 inhibitor
化学名： 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
纯度： ≥97% (HPLC)
生物活性 for PF 06726304 acetate
PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 06726304 acetate
| 分子量 | 506.38 |
| 公式 | C22H21Cl2N3O3.C2H4O2 |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 2080306-28-9 |
| PubChem ID | 124201861 |
| InChI Key | AVDCFFPRJKOOLX-UHFFFAOYSA-N |
| Smiles | ClC1=C(C(N(CC2=C(C)C=C(C)NC2=O)CC3)=O)C3=C(Cl)C=C1C4=C(C)ON=C4C.CC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PF 06726304 acetate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 50.64 | 100 | |
| ethanol | 50.64 | 100 |
制备储备液 for PF 06726304 acetate
以下数据基于产品分子量 506.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.87 mL | 19.75 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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产品说明书 for PF 06726304 acetate
参考文献 for PF 06726304 acetate
参考文献是支持产品生物活性的出版物。
Kung et al (2016) Design and synthesis of pyridone-containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of enhancer of zeste homolog 2 (EZH2) inhibitors. J.Med.Chem. 59 8306 PMID: 27512831
If you know of a relevant reference for PF 06726304 acetate, please let us know.
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关键词: PF 06726304 acetate, PF 06726304 acetate supplier, PF06726304, acetate, highly, potent, EZH2, inhibitors, inhibits, enhancer, of, zeste, homolog, 2, lysine, methyltransferase, PRC2, polycomb, repressive, complex, Lysine, Methyltransferases, 6169, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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