PF 3845

Cat. No. 4175 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective FAAH inhibitor

化学名： N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide

纯度： ≥99% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 3845

PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (K_i = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC₅₀ >10 μM).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for PF 3845

分子量	456.46
公式	C₂₄H₂₃F₃N₄O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1196109-52-0
PubChem ID	25154867
InChI Key	NBOJHRYUGLRASX-UHFFFAOYSA-N
Smiles	O=C(NC2=CN=CC=C2)N1CCC(CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 3845

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	45.65	100
	ethanol	22.82	50

制备储备液 for PF 3845

以下数据基于产品分子量 456.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.91 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.1 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for PF 3845

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 3845

参考文献是支持产品生物活性的出版物。

Ahn et al (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 16 411 PMID: 19389627

Ahn et al (2009) Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 4 763 PMID: 20544003

If you know of a relevant reference for PF 3845, please let us know.

按标靶查看相关产品

关键词: PF 3845, PF 3845 supplier, pfizer, cannabinoid, receptors, fatty, acid, amide, hydrolase, FAAH, inhibitors, inhibits, PF3845, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4175, Tocris Bioscience

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