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Submit ReviewPF 5081090
说明： Potent LpxC inhibitor
化学名： (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide
纯度： ≥98% (HPLC)
生物活性 for PF 5081090
Potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa); effective against a range of gram negative bacteria.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 5081090
| 分子量 | 412.43 |
| 公式 | C18H21FN2O6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1312473-63-4 |
| PubChem ID | 56964907 |
| InChI Key | DNVUWHWBCMGQLU-GOSISDBHSA-N |
| Smiles | O=C1N(CC[C@]([S@@](C)(=O)=O)(C)C(NO)=O)C=CC(C2=CC=C(OC)C=C2F)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 5081090
参考文献 for PF 5081090
参考文献是支持产品生物活性的出版物。
Montgomery et al (2012) Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J.Med.Chem. 55 1662 PMID: 22257165
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