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Submit ReviewPF 514273
说明： High affinity and selective CB1 antagonist
化学名： 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
纯度： ≥98% (HPLC)
生物活性 for PF 514273
PF 514273 is a high affinity and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
技术数据 for PF 514273
| 分子量 | 452.28 |
| 公式 | C21H17Cl2F2N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 851728-60-4 |
| PubChem ID | 11316919 |
| InChI Key | FJMQJSUOOGOWBD-UHFFFAOYSA-N |
| Smiles | O=C2C1=NN(C4=CC=CC=C4Cl)C(C3=CC=C(Cl)C=C3)=C1OCCN2CC(C)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 514273
参考文献 for PF 514273
参考文献是支持产品生物活性的出版物。
Dow et al (2009) Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of J.Med.Chem. 52 2652 PMID: 19351113
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关键词: PF 514273, PF 514273 supplier, Potent, and, selective, CB1, agonists, cannabinoids, Receptors, PF514273, cb1r, 3676, Tocris Bioscience
1 篇 PF 514273 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PF 514273 的部分引用包括：
Rozenfeld et al (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30 2350 PMID: 21540834
PF 514273 的评论
平均评分: 4 (Based on 1 Review.)
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Works as described.
By
Anonymous on 05/14/2019
分析类型： In Vivo
种属： Mouse
Used in vivo for mouse behavioral work to test CB1 receptor involvement in alcohol reward learning and seeking behavior. Data show product did work centrally, as it reduced locomotor activity.
Drug can be difficult to get into solution, as would be expected for a cannabinoid compound. So don't expect to use high concentrations unless you are OK w/ using in suspension.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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