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Submit ReviewPF 6274484
说明： High affinity and potent covalent EGFR kinase inhibitor
化学名： N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
纯度： ≥98% (HPLC)
生物活性 for PF 6274484
PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50 values are 5.8 and 6.6 nM, respectively).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 6274484
| 分子量 | 372.78 |
| 公式 | C18H14ClFN4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1035638-91-5 |
| PubChem ID | 74766099 |
| InChI Key | TUYDDIWQXWTNSW-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1NC(C=C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 6274484
参考文献 for PF 6274484
参考文献是支持产品生物活性的出版物。
Schwartz et al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 111 173 PMID: 24347635
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关键词: PF 6274484, PF 6274484 supplier, PF6274484, epidermal, growth, factor, receptors, EGFR, kinase, inhibitors, inhibits, potent, high, affinity, covalent, 5939, Tocris Bioscience
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