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Submit ReviewPF 945863
说明： Macrolide antibiotic
化学名： (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone
纯度： ≥98% (HPLC)
生物活性 for PF 945863
PF 945863 is a macrolide antibiotic. Active against multidrug resistant respiratory tract bacterial strains. Does not have the hepatotoxic side effects associated with telithromycin. Orally active.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 945863
| 分子量 | 824.01 |
| 公式 | C44H65N5O10 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 893556-85-9 |
| PubChem ID | 90488939 |
| InChI Key | FATPJRUUPNLGGR-ACVHMLGSSA-N |
| Smiles | O=C(N2C3CN([C@H](C)C4=C(C=CC=N5)C5=NC=C4)C3)O[C@](C2[C@H]1C)(C)[C@@H](CC)OC([C@H](C)C([C@H](C)[C@@H](O[C@@]6([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O6)[C@](C)(OC)C[C@@H](C)C1=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 945863
参考文献 for PF 945863
参考文献是支持产品生物活性的出版物。
Magee et al (2009) Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J.Med.Chem. 52 7446 PMID: 19775168
Zientek et al (2010) In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab.Dispos. 38 1322 PMID: 20444863
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关键词: PF 945863, PF 945863 supplier, PF945863, macrolide, antibiotics, multidrug, resistant, respiratory, tract, bacterial, Antibiotics, 4419, Tocris Bioscience
PF 945863 的评论
平均评分: 5 (Based on 1 Review.)
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Product used on mutated E.coli strains to see how the antibiotic strengths differ.
By
Richard Whiteoak on 01/24/2019
分析类型： In Vitro
种属： Other
PF 945863 was plated to measure antibiotic strength against mutated E.Coli strains.
