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Submit ReviewPG 931
说明： Potent and selective MC4 receptor agonist
生物活性 for PG 931
PG 931 is a potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
技术数据 for PG 931
| 分子量 | 1180.41 |
| 公式 | C59H85N15O11 |
| 序列 |
XDPFRWKPV (Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized) |
| 储存 | Store at -20°C |
| CAS Number | 667430-81-1 |
| PubChem ID | 90489007 |
| InChI Key | WOFDJLFPEWSAPJ-RVBGBMFGSA-N |
| Smiles | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PG 931
参考文献 for PG 931
参考文献是支持产品生物活性的出版物。
Giuliani et al (2007) Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br.J.Pharmacol. 150 595 PMID: 17245369
Grieco et al (2003) Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J.Pept.Res. 62 199 PMID: 14531843
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关键词: PG 931, PG 931 supplier, PG931, Potent, selective, MC4R, receptors, agonists, Melanocortin, Receptors, 5094, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.