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Submit ReviewPhencyclidine hydrochloride
说明： Non-competitive NMDA antagonist
别名： PCP
化学名： 1-(1-Phenylcyclohexyl)piperidine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Phencyclidine hydrochloride
Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.
技术数据 for Phencyclidine hydrochloride
| 分子量 | 279.85 |
| 公式 | C17H25N.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 956-90-1 |
| PubChem ID | 13727 |
| InChI Key | BUAJNGPDPGKBGV-UHFFFAOYSA-N |
| Smiles | N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Phencyclidine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.19 | 40 |
制备储备液 for Phencyclidine hydrochloride
以下数据基于产品分子量 279.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 8.93 mL | 44.67 mL | 89.33 mL |
| 2 mM | 1.79 mL | 8.93 mL | 17.87 mL |
| 4 mM | 0.89 mL | 4.47 mL | 8.93 mL |
| 20 mM | 0.18 mL | 0.89 mL | 1.79 mL |
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产品说明书 for Phencyclidine hydrochloride
参考文献 for Phencyclidine hydrochloride
参考文献是支持产品生物活性的出版物。
Linders et al (1993) Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 36 2499 PMID: 8355251
Jin et al (1997) The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 319 147 PMID: 9042584
Sharp (1997) Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 758 51 PMID: 9203533
If you know of a relevant reference for Phencyclidine hydrochloride, please let us know.
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关键词: Phencyclidine hydrochloride, Phencyclidine hydrochloride supplier, σ, sigma, receptor, agonists, Non-competitive, NMDA, antagonists, General, Receptors, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, PCP, Sigma-Related, 2557, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
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