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Submit ReviewPhentolamine Mesylate
说明： Adrenergic α receptor antagonist; antihypertensive
化学名： 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol methanesulfonate
纯度： ≥98% (HPLC)
生物活性 for Phentolamine Mesylate
Phentolamine Mesylate is a non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.
化合物库 for Phentolamine Mesylate
Phentolamine Mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Phentolamine Mesylate
| 分子量 | 377.46 |
| 公式 | C17H19N3O.CH4O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 65-28-1 |
| PubChem ID | 91430 |
| InChI Key | OGIYDFVHFQEFKQ-UHFFFAOYSA-N |
| Smiles | CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Phentolamine Mesylate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 37.75 | 100 | |
| DMSO | 37.75 | 100 |
制备储备液 for Phentolamine Mesylate
以下数据基于产品分子量 377.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for Phentolamine Mesylate
参考文献 for Phentolamine Mesylate
参考文献是支持产品生物活性的出版物。
Liu & Coupar (1996) Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 117 787 PMID: 8851491
Fioretti et al (2017) Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 99 53 PMID: 28986330
Nonogaki & Kaji (2017) α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 18 35 PMID: 27939978
If you know of a relevant reference for Phentolamine Mesylate, please let us know.
关键词: Phentolamine Mesylate, Phentolamine Mesylate supplier, Phentolamine, non, selective, alpha, adrenergic, receptor, antagonists, antagonism, antihypertensive, adrenoceptor, Non-selective, Adrenergic, Alpha, Receptors, 6431, Tocris Bioscience
2 篇 Phentolamine Mesylate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Phentolamine Mesylate 的部分引用包括：
Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823
David R et al (2021) Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux. Front Oncol 10 614288 PMID: 33598432
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.