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Submit ReviewPhlorizin
说明： Na+-glucose cotransporter (SGLT) inhibitor
化学名： 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
纯度： ≥99% (HPLC)
生物活性 for Phlorizin
Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
技术数据 for Phlorizin
| 分子量 | 436.41 |
| 公式 | C21H24O10 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 60-81-1 |
| PubChem ID | 6072 |
| InChI Key | IOUVKUPGCMBWBT-QNDFHXLGSA-N |
| Smiles | O=C(CCC2=CC=C(O)C=C2)C1=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Phlorizin
参考文献 for Phlorizin
参考文献是支持产品生物活性的出版物。
Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496
Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123
Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510
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关键词: Phlorizin, Phlorizin supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 4627, Tocris Bioscience
1 篇 Phlorizin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Phlorizin 的部分引用包括：
Smith et al (2018) T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways. Mol Metab 17 98 PMID: 30201274
Phlorizin 的评论
平均评分: 5 (Based on 1 Review.)
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Phlorizin inhibits LPS-induced iNOS in HL-1 cells.
By
Chintan Koyani on 10/22/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： cardiomyocytes
HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).
