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MSC 4381

Cat. No. 8008 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
Chemical Name: 5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MSC 4381

MSC 4381 is a potent and selective monocarboxylate transporter 4 (MCT4) inhibitor (IC50 = 77 nM; Ki = 11 nM). Inhibits lactate efflux in MDA-MB-231 cells (IC50 = 1 nM) and reduces viability of cells expressing high levels of MCT4.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 4381 probe summary on the SGC website.

Technical Data for MSC 4381

M. Wt 537.97
Formula C26H20ClN3O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2445185-57-7
PubChem ID 150189198
InChI Key FNBUZGRPJLEIMO-UHFFFAOYSA-N
Smiles O=C(C1=NC=C(C(OC)=C1)C#CC2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C4=CC=CN=C43)OCC)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MSC 4381

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.9 50

Preparing Stock Solutions for MSC 4381

The following data is based on the product molecular weight 537.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.72 mL 18.59 mL 37.18 mL
2.5 mM 0.74 mL 3.72 mL 7.44 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
25 mM 0.07 mL 0.37 mL 0.74 mL

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References for MSC 4381

References are publications that support the biological activity of the product.

Heinrich et al (2021) Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid, a highly selective in vivo eseable chemical probe to dissect MCT4 biology. J.Med.Chem. 64 11904 PMID: 34382802

If you know of a relevant reference for MSC 4381, please let us know.

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Keywords: MSC 4381, MSC 4381 supplier, MSC4381, MCT4, monocarboxylate, transporter, 4, inhibitor, inhibitors, inhibits, lactate, efflux, cell, viability, Monocarboxylate, Transporters, 8008, Tocris Bioscience

Citations for MSC 4381

Citations are publications that use Tocris products.

Currently there are no citations for MSC 4381. Do you know of a great paper that uses MSC 4381 from Tocris? Please let us know.

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