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Phrixotoxin 3

Cat. No. 4914 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent blocker of NaV1.2, NaV1.3 and NaV1.5 channels
纯度： ≥95% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Phrixotoxin 3

Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.

技术数据 for Phrixotoxin 3

分子量 4059.74
公式 C176H269N51O48S6
序列 DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI

(Modifications: Disulfide bridges: 2-17, 9-23, 16-30)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 880886-00-0
PubChem ID 90488989
InChI Key SOKDRDMJNDICMO-UHFFFAOYSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Phrixotoxin 3

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Phrixotoxin 3

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Phrixotoxin 3

参考文献是支持产品生物活性的出版物。

Bosmans et al (2006) Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol.Pharmacol. 69 419 PMID: 16267209

Ono et al (2011) Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 58 265 PMID: 21740921

If you know of a relevant reference for Phrixotoxin 3, please let us know.

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关键词: Phrixotoxin 3, Phrixotoxin 3 supplier, modulators, modulates, sodium, voltage-gated, channels, NaV1.2, NaV1.3, NaV1.5, venoms, Voltage-gated, Sodium, Channels, 4914, Tocris Bioscience

篇 Phrixotoxin 3 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Phrixotoxin 3 的评论

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Study of the depolarizing shift in gating kinetics by Phrixotoxin 3.
By Anonymous on 01/16/2020
分析类型： In Vivo
种属： Mouse

We studied the depolarizing shift in gating kinetics and blocking of the inward component of the sodium current by Phrixotoxin 3.

review image