Picropodophyllotoxin

Cat. No. 2956 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective IGF1R inhibitor

别名： Picropodophyllin

化学名： (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

纯度： ≥97% (HPLC)

引用文献 (3)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Picropodophyllotoxin

Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC₅₀ ~ 1 nM), increases the fraction of cells in the G₂/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC₅₀ = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.

技术数据 for Picropodophyllotoxin

分子量	414.41
公式	C₂₂H₂₂O₈
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	477-47-4
PubChem ID	72435
InChI Key	YJGVMLPVUAXIQN-HAEOHBJNSA-N
Smiles	O=C3OC[C@]([C@@]([H])3[C@@H]4[C@]5=CC(OC)=C(OC)C(OC)=C5)([H])[C@@H](O)C1=C4C=C(OCO2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Picropodophyllotoxin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.44	100

制备储备液 for Picropodophyllotoxin

以下数据基于产品分子量 414.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for Picropodophyllotoxin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Picropodophyllotoxin

参考文献是支持产品生物活性的出版物。

Girnita et al (2004) Cyclolignans as inhibitors of the Ins-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64 236 PMID: 14729630

Stromberg et al (2006) IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G₂/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107 669 PMID: 16166596

Economou et al (2008) Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the Ins-like growth factor-1 receptor. Invest.Ophthalmol.Vis.Sci. 49 2620 PMID: 18515591

If you know of a relevant reference for Picropodophyllotoxin, please let us know.

按标靶查看相关产品

关键词: Picropodophyllotoxin, Picropodophyllotoxin supplier, Selective, IGF1R, inhibitors, inhibits, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, Picropodopyhllin, Picropodophyllin, Insulin, and, insulin-like, 2956, Tocris Bioscience

3 篇 Picropodophyllotoxin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Picropodophyllotoxin 的部分引用包括：

Stouffer et al (2015) Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543 PMID: 26503322

Forster et al (2019) Macrophage-derived Ins.-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis. FASEB J fj201900797R PMID: 31291762

Tarnowski (2017) Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo. BMC Cancer 17 532 PMID: 28793874

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Pathways for Picropodophyllotoxin

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.