Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPifithrin-μ
说明： Inhibitor of p53-mitochondrial binding
别名： NSC 303580
化学名： 2-Phenylethynesulfonamide
纯度： ≥99% (HPLC)
生物活性 for Pifithrin-μ
Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
技术数据 for Pifithrin-μ
| 分子量 | 181.21 |
| 公式 | C8H7NO2S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 64984-31-2 |
| PubChem ID | 327653 |
| InChI Key | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C#CC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pifithrin-μ
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 13.12 | 100 | |
| ethanol | 13.12 | 100 |
制备储备液 for Pifithrin-μ
以下数据基于产品分子量 181.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.52 mL | 27.59 mL | 55.18 mL |
| 5 mM | 1.1 mL | 5.52 mL | 11.04 mL |
| 10 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.1 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Pifithrin-μ
参考文献 for Pifithrin-μ
参考文献是支持产品生物活性的出版物。
Strom et al (2006) Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2 474 PMID: 16862141
Leu et al (2009) A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 36 15 PMID: 19818706
Kawamura et al (2009) Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 460 1140 PMID: 19668186
Steele et al (2009) 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 114 1217 PMID: 19515722
If you know of a relevant reference for Pifithrin-μ, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Pifithrin-mu, Pifithrin-mu supplier, inhibitors, inhibits, p53-mitochondrial, binding, Transcription, Factors, MDM2, p14ARF, Pifithrin-mu, NSC303580, NSC, 303580, p53, Stem, Cell, Reprogramming, Hsp70, 2653, Tocris Bioscience
6 篇 Pifithrin-μ 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pifithrin-μ 的部分引用包括：
Kojima et al (2010) The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther 9 2545 PMID: 20736344
Li et al (2018) Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development 145 PMID: 30545932
Nemade et al (2018) Cell death mechanisms of the anti-cancer drug EPEG on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol 92 1507 PMID: 29397400
Xia et al (2014) EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int 2014 348728 PMID: 24745014
Blatzer et al (2015) Blocking Hsp70 Enhances the Efficiency of amphote. B Treatment against Resistant Aspergillus terreus Strains. Antimicrob Agents Chemother 59 3778 PMID: 25870060
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. PLoS One 2013 857929 PMID: 23762164
您是否知道使用了 Tocris Pifithrin-μ 的优秀论文？ 请告知我们.
Pifithrin-μ 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Pifithrin-μ?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Pifithrin-μ.
By
Anonymous on 07/12/2020
分析类型： In Vivo
种属： Mouse
细胞系/组织： neural cell
Pifithrin-µ were dissolved in DMSO and used at a final concentration of 50 µM for pifithrin-µ according to previous studies in which 10-50 µM pifithrin-µ were employed.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for Pifithrin-μ
