Pilocarpine hydrochloride

Pricing Availability   Qty
说明: Muscarinic agonist
化学名: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)

生物活性 for Pilocarpine hydrochloride

Pilocarpine hydrochloride is an M3 muscarinic acetycholine receptor agonist.

化合物库 for Pilocarpine hydrochloride

Pilocarpine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Pilocarpine hydrochloride

分子量 244.72
公式 C11H16N2O2.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 54-71-7
PubChem ID 5909
InChI Key RNAICSBVACLLGM-GNAZCLTHSA-N
Smiles O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pilocarpine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.35 75
water 24.47 100

制备储备液 for Pilocarpine hydrochloride

以下数据基于产品分子量 244.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.43 mL 40.86 mL
5 mM 0.82 mL 4.09 mL 8.17 mL
10 mM 0.41 mL 2.04 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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产品说明书 for Pilocarpine hydrochloride

分析证书/产品说明书
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参考文献 for Pilocarpine hydrochloride

参考文献是支持产品生物活性的出版物。

ten Berge et al (1996) Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659

Wang et al (1999) PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814

Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147

Merck Index 12 7578


If you know of a relevant reference for Pilocarpine hydrochloride, please let us know.

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查看全部 Non-selective Muscarinic Agonists

关键词: Pilocarpine hydrochloride, Pilocarpine hydrochloride supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0694, Tocris Bioscience

3 篇 Pilocarpine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pilocarpine hydrochloride 的部分引用包括:

Overby et al (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice. Nat Chem Biol 55 3727 PMID: 24833737

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438


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