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Submit ReviewPiribedil dihydrochloride
说明： Dopamine agonist
化学名： 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for Piribedil dihydrochloride
Piribedil dihydrochloride is a direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
技术数据 for Piribedil dihydrochloride
| 分子量 | 371.27 |
| 公式 | C16H18N4O2.2HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1451048-94-4 |
| PubChem ID | 3038520 |
| InChI Key | VRSRBPOCDOKYKT-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Piribedil dihydrochloride
参考文献 for Piribedil dihydrochloride
参考文献是支持产品生物活性的出版物。
Cagnotto et al (1996) In vitro affinity of piribedil for DA D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63 PMID: 8905329
Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2 PMID: 1634907
Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomor. and the 'atypical DA agonists' (piribedil and S36080). Life Sci. 38 895 PMID: 3081774
Merck Index 12 7648
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关键词: Piribedil dihydrochloride, Piribedil dihydrochloride supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1031, Tocris Bioscience
1 篇 Piribedil dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Piribedil dihydrochloride 的部分引用包括：
Rodrigues et al (2014) Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar DArgic D2 activity after REM sleep deprivation. Front Cell Neurosci 8 383 PMID: 25520618
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.