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Pitavastatin calcium

Cat. No. 4942 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： HMG-CoA reductase inhibitor
别名： NK-104
化学名： (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pitavastatin calcium

Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

化合物库 for Pitavastatin calcium

Pitavastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Pitavastatin calcium

分子量 440.5
公式 C25H23FNO4.0.5Ca
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 147526-32-7
PubChem ID 5282451
InChI Key RHGYHLPFVJEAOC-FFNUKLMVSA-L
Smiles [Ca++].O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pitavastatin calcium

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.05 100

制备储备液 for Pitavastatin calcium

以下数据基于产品分子量 440.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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产品说明书 for Pitavastatin calcium

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Pitavastatin calcium

参考文献是支持产品生物活性的出版物。

Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770 PMID: 16810078

Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239 PMID: 15854203

Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904 PMID: 9296275

If you know of a relevant reference for Pitavastatin calcium, please let us know.

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关键词: Pitavastatin calcium, Pitavastatin calcium supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, HMG-CoA, Reductase, 4942, Tocris Bioscience

1 篇 Pitavastatin calcium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pitavastatin calcium 的部分引用包括：

Laurent et al (2021) Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel) 13 PMID: 34439123

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