PKI 166 hydrochloride

Name: PKI 166 hydrochloride
Brand: Tocris Bioscience
SKU: 4941

Cat. No. 4941 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4941 has been discontinued.

View all EGFR products.

说明： Potent EGFR-kinase inhibitor

化学名： 4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for PKI 166 hydrochloride

PKI 166 hydrochloride is a potent EGFR-kinase inhibitor (IC₅₀ = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable.

技术数据 for PKI 166 hydrochloride

分子量	366.84
公式	C₂₀H₁₈N₄O.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2230253-82-2
PubChem ID	91691117
InChI Key	ZPTWAAIZEGWMGX-BTQNPOSSSA-N
Smiles	OC(C=C3)=CC=C3C2=CC1=C(N[C@@H]([C@]4=CC=CC=C4)C)N=CN=C1N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PKI 166 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PKI 166 hydrochloride

参考文献是支持产品生物活性的出版物。

Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID: 10850439

Ulu et al (2013) Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. J.Pharmacol.Exp.Ther. 345 393 PMID: 23528611

Kaspersen et al (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorg.Chem. 44 35 PMID: 22832269

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篇 PKI 166 hydrochloride 的引用文献

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目前没有 PKI 166 hydrochloride 的引用文献。