PKRA 7

Cat. No. 6238 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

别名： PROK2 Antagonist,Bv8 Antagonist,PK2 Antagonist,Prokineticin 2 Antagonist

化学名： (3R)-N-[(9-Chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PKRA 7

PKRA 7 is a potent prokineticin (PK) receptor antagonist (IC₅₀ values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo. Brain penetrant. Cell-permeable.

技术数据 for PKRA 7

分子量	541.48
公式	C₂₇H₃₄ClFN₂O₄.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
InChI Key	ICBJJRUEQVVDRU-ZMBIFBSDSA-N
Smiles	FC1=C(OC)C=C(CN2CC[C@H](C2)C(N(CC(C)C)CC3=CC(Cl)=C4OCCCOC4=C3)=O)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PKRA 7

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	54.15	100

制备储备液 for PKRA 7

以下数据基于产品分子量 541.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.23 mL	18.47 mL
5 mM	0.37 mL	1.85 mL	3.69 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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产品说明书 for PKRA 7

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PKRA 7

参考文献是支持产品生物活性的出版物。

Ito et al (2016) Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. BMC Musculoskelet.Disord. 17 387 PMID: 27609223

Curtis et al (2013) A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. PLoS One 8 e54916 PMID: 23372791

If you know of a relevant reference for PKRA 7, please let us know.

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关键词: PKRA 7, PKRA 7 supplier, 1233926-87-8, PKRA7, PKRA_7, potent, prokineticin2, PROK2, PK2, Bv8, PROKR1, PKR1, PKR2, antagonists, antagonises, antagonizes, antagonism, brain, penetrant, Antagonist, Prokineticin, 2, Other, Peptide, Receptors, 6238, Tocris Bioscience

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