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Pluripotin

Cat. No. 4433 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4433 has been discontinued.

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说明： Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
别名： SC1
化学名： N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
实验方案 (1)
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Pluripotin

Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).

技术数据 for Pluripotin

分子量 550.54
公式 C27H25F3N8O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 839707-37-8
PubChem ID 12003241
InChI Key NBZFRTJWEIHFPF-UHFFFAOYSA-N
Smiles CN2C1=NC(NC4=CC(C)=NN4C)=NC=C1CN(C3=CC(NC(C5=CC(C(F)(F)F)=CC=C5)=O)=CC=C3C)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Pluripotin

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化学品安全技术说明书

参考文献 for Pluripotin

参考文献是支持产品生物活性的出版物。

Wu and Ding et al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3 255

Chen et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266 PMID: 17088537

Mertins et al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099 PMID: 23437320

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关键词: Pluripotin, Pluripotin supplier, dual, inhibitors, inhibits, extracellular, signal-regulated, kinase, 1, ERK1, MAPK3, mitogen-activated, protein, 3, RasGAP, mouse, murine, stem, cells, self-renewal, SC1, ERK, Stem, Cell, Proliferation, 4433, Tocris Bioscience

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Pluripotin 实验方案

以下实验方案包含使用 Pluripotin（目录编号 4433）的更多信息。

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for Pluripotin

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.