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Submit Review(+)-AJ 76 hydrochloride
说明： Antagonist; preferential action at D2-like autoreceptors
化学名： (1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride
生物活性 for (+)-AJ 76 hydrochloride
(+)-AJ 76 hydrochloride is a dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
技术数据 for (+)-AJ 76 hydrochloride
| 分子量 | 269.81 |
| 公式 | C15H23NO.HCl |
| 储存 | Store at RT |
| CAS Number | 85378-82-1 |
| PubChem ID | 13755572 |
| InChI Key | KIRYNZFMOLYYQB-YECZQDJWSA-N |
| Smiles | Cl.CCCN[C@@H]1CCC2=C(OC)C=CC=C2[C@@H]1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (+)-AJ 76 hydrochloride
参考文献 for (+)-AJ 76 hydrochloride
参考文献是支持产品生物活性的出版物。
Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists. J.Med.Chem. 30 602 PMID: 3560156
Kullingsjo et al (1991) Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241 PMID: 1817961
Millan et al (2004) The role of DA D3 compared with DA D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341 PMID: 14985929
Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo. Eur.J.Pharmacol. 251 181 PMID: 8149975
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.