(+)-Igmesine hydrochloride

Cat. No. 2332 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective σ₁ ligand; antidepressant

化学名： (R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is a selective σ₁ receptor ligand (K_D = 19.1 nM), with little or no activity at σ₂ receptors (IC₅₀ > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC₅₀ value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for (+)-Igmesine hydrochloride

分子量	355.94
公式	C₂₃H₂₉N.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	130152-35-1
PubChem ID	6438339
InChI Key	SCHQQPAJNUHKSV-RSGUCCNWSA-N
Smiles	CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (+)-Igmesine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	17.8	50

制备储备液 for (+)-Igmesine hydrochloride

以下数据基于产品分子量 355.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.62 mL	28.09 mL	56.19 mL
2.5 mM	1.12 mL	5.62 mL	11.24 mL
5 mM	0.56 mL	2.81 mL	5.62 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

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产品说明书 for (+)-Igmesine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (+)-Igmesine hydrochloride

参考文献是支持产品生物活性的出版物。

Akunne et al (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 41 138 PMID: 11445194

O'Neill et al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 283 217 PMID: 7498313

If you know of a relevant reference for (+)-Igmesine hydrochloride, please let us know.

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