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Submit Review(+)-PD 128907 hydrochloride
说明： High affinity D3 agonist (D3 ≥ D2 > D4)
化学名： (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for (+)-PD 128907 hydrochloride
(+)-PD 128907 hydrochloride is a high affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.
技术数据 for (+)-PD 128907 hydrochloride
| 分子量 | 285.77 |
| 公式 | C14H19NO3.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 300576-59-4 |
| PubChem ID | 11957668 |
| InChI Key | DCFXOTRONMKUJB-QMDUSEKHSA-N |
| Smiles | CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (+)-PD 128907 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 2.86 | 10 |
制备储备液 for (+)-PD 128907 hydrochloride
以下数据基于产品分子量 285.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.99 mL | 174.97 mL | 349.93 mL |
| 0.5 mM | 7 mL | 34.99 mL | 69.99 mL |
| 1 mM | 3.5 mL | 17.5 mL | 34.99 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7 mL |
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产品说明书 for (+)-PD 128907 hydrochloride
参考文献 for (+)-PD 128907 hydrochloride
参考文献是支持产品生物活性的出版物。
Bristow et al (1996) The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203
Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103
Witkin et al (1998) Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997
If you know of a relevant reference for (+)-PD 128907 hydrochloride, please let us know.
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关键词: (+)-PD 128907 hydrochloride, (+)-PD 128907 hydrochloride supplier, D3, agonists, D2, D4, Dopamine, Receptors, dopaminergic, (+)-PD128907, hydrochloride, PD128907, 1243, Tocris Bioscience
9 篇 (+)-PD 128907 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (+)-PD 128907 hydrochloride 的部分引用包括：
Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653
Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Neurosci Lett 283 26016 PMID: 18644790
Cote and Kuzhikandathil (2015) Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease. J Neurosci 585 33 PMID: 25445374
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
Shin et al (2018) Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. Neuron 97 195 PMID: 29276054
Basso et al (2005) Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30 1257 PMID: 15688083
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
Zhang et al (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the DA D1 and D3 receptors. J Neurosci 24 3344 PMID: 15056714
Clemens and Hochman (2004) Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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