PLX 647 dihydrochloride

Name: PLX 647 dihydrochloride
Brand: Tocris Bioscience
SKU: 5102

Cat. No. 5102 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5102 has been discontinued.

View all Other RTKs products.

说明： Potent dual Fms/KIT inhibitor

化学名： 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for PLX 647 dihydrochloride

PLX 647 dihydrochloride is a potent dual KIT/Fms inhibitor (IC₅₀ values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC₅₀ values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

技术数据 for PLX 647 dihydrochloride

分子量	455.3
公式	C₂₁H₁₇F₃N₄.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1779796-38-1
PubChem ID	78243730
InChI Key	MVMKWLRKACAUTB-UHFFFAOYSA-N
Smiles	FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PLX 647 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PLX 647 dihydrochloride

参考文献是支持产品生物活性的出版物。

Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID: 23493555

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other RTKs Inhibitors

关键词: PLX 647 dihydrochloride, PLX 647 dihydrochloride supplier, PLX647, dihydrochloride, potent, selective, FMS, KIT, dual, inhibitors, kinases, proliferation, antiproliferative, differentiation, osteoclasts, inhibits, Other, RTKs, 5102, Tocris Bioscience

篇 PLX 647 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 PLX 647 dihydrochloride 的引用文献。