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Submit ReviewPM 226
说明： Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective
化学名： 7-(1,1-Dimethylheptyl)-9-methoxy-4,4-dimethyl-4H-[1]benzopyrano[3,4-d]isoxazole
纯度： ≥98% (HPLC)
生物活性 for PM 226
PM 226 is a potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.
技术数据 for PM 226
| 分子量 | 357.49 |
| 公式 | C22H31NO3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1949726-13-9 |
| PubChem ID | 132510986 |
| InChI Key | VFWIRWAAMNBBFG-UHFFFAOYSA-N |
| Smiles | CCCCCCC(C)(C1=CC(OC)=C2C3=C(C(C)(OC2=C1)C)C=NO3)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PM 226
参考文献 for PM 226
参考文献是支持产品生物活性的出版物。
Navarro et al (2016) Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders. Front. Neurosci. 10 406 PMID: 27679556
Morales et al (2016) Chromenopyrazole, a versatile cannabinoid scaffold with in vivo activity in a model of multiple sclerosis. J.Med.Chem. 59 6753 PMID: 27309150
Gómez-Cañas et al (2016) Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile. Pharmacol.Res. 110 205 PMID: 27013280
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关键词: PM 226, PM 226 supplier, PM226, Potent, selective, CB2, agonists, agonism, BBB, permeable, anti-inflammatory, neuroprotective, cannabinoids, receptors, Receptors, 6220, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.