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Submit ReviewPMPA (NMDA antagonist)
说明： Competitive NMDA antagonist
别名： PMPC
化学名： 4-(Phosphonomethyl)-2-piperazinecarboxylic acid
生物活性 for PMPA (NMDA antagonist)
PMPA (NMDA antagonist) is a competitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for PMPA (NMDA antagonist)
| 分子量 | 224.15 |
| 公式 | C6H13N2O5P |
| 储存 | Store at +4°C |
| CAS Number | 113919-36-1 |
| PubChem ID | 17756792 |
| InChI Key | ILRBBHJXTYIHTP-UHFFFAOYSA-N |
| Smiles | OP(CN1CC(C(O)=O)NCC1)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PMPA (NMDA antagonist)
参考文献 for PMPA (NMDA antagonist)
参考文献是支持产品生物活性的出版物。
Harris and Davies (1992) Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7. Brain Res. 594 176 PMID: 1361408
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
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关键词: PMPA (NMDA antagonist), PMPA (NMDA antagonist) supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, PMPC, 2273, Tocris Bioscience
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Antagonism at NMDA receptor.
By
Sergiy Sylantyev on 11/29/2020
种属： Human
PMPA was in use as an NMDA receptor antagonist affecting glutamate site, to study (possible) competition of dopamine for this site. Application of PMPA and dopamine mixtures in different ratios resulted in a decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in water up to 10 mM concentration.
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