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说明： Potent and selective 5-HT1D agonist
化学名： (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide
纯度： ≥98% (HPLC)
生物活性 for PNU 109291
Potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.
技术数据 for PNU 109291
| 分子量 | 409.52 |
| 公式 | C24H31N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 187665-60-7 |
| PubChem ID | 9909448 |
| InChI Key | UDLSEQDYARNKTL-QHCPKHFHSA-N |
| Smiles | O=C(NC)C3=CC(CCO2)=C(C=C3)[C@@H]2CCN1CCN(C4=CC=C(OC)C=C4)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PNU 109291
参考文献 for PNU 109291
参考文献是支持产品生物活性的出版物。
Ennis et al (1998) Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J.Med.Chem. 41 2180 PMID: 9632349
Bhattacharya et al (2004) 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium. J.Pharmacol.Exp.Ther. 309 825 PMID: 14724223
Cutrer et al (1999) Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology 38 1043 PMID: 10428423
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关键词: PNU 109291, PNU 109291 supplier, Potent, selective, 5-HT1D, agonists, Serotonin, Receptors, PNU109291, 2556, Tocris Bioscience
1 篇 PNU 109291 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PNU 109291 的部分引用包括：
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. J Mol Neurosci 3 e00103 PMID: 25692021
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.