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Submit ReviewPNU 177864 hydrochloride
说明： Highly selective D3 antagonist
化学名： N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for PNU 177864 hydrochloride
PNU 177864 hydrochloride is a highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.
技术数据 for PNU 177864 hydrochloride
| 分子量 | 438.89 |
| 公式 | C18H21F3N2O3S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1783978-03-9 |
| PubChem ID | 56972219 |
| InChI Key | UOMDLHQTLPWCCE-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PNU 177864 hydrochloride
参考文献 for PNU 177864 hydrochloride
参考文献是支持产品生物活性的出版物。
Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318 PMID: 15204973
Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with DA D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326 PMID: 15204974
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关键词: PNU 177864 hydrochloride, PNU 177864 hydrochloride supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, PNU177864, hydrochloride, 3355, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.