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Submit ReviewPNU 22394 hydrochloride
说明： 5-HT2C agonist and 5-HT2A/2B partial agonist
化学名： 1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride
纯度： ≥99% (HPLC)
生物活性 for PNU 22394 hydrochloride
PNU 22394 hydrochloride is a potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.
技术数据 for PNU 22394 hydrochloride
| 分子量 | 236.74 |
| 公式 | C13H16N2.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 15923-42-9 |
| PubChem ID | 27558 |
| InChI Key | SAIGGEUWSYESTR-UHFFFAOYSA-N |
| Smiles | Cl.CN1C2=C(CCNCC2)C2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PNU 22394 hydrochloride
参考文献 for PNU 22394 hydrochloride
参考文献是支持产品生物活性的出版物。
McCall et al (2001) PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Soc.Neurosci.Abstr. 27 309
Jensen et al (2013) Design, synthesis and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211
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关键词: PNU 22394 hydrochloride, PNU 22394 hydrochloride supplier, 5-HT2C, agonists, 5-HT2A/2B, partial, Serotonin, Receptors, 5-HT2, 5-HT2A, PNU22394, hydrochloride, 2201, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.