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PQ 69

Cat. No. 5351 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5351 has been discontinued.

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说明： Potent and selective A1 inverse agonist
化学名： 4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for PQ 69

PQ 69 is a potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.

技术数据 for PQ 69

分子量 350.39
公式 C20H19FN4O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 910045-32-8
PubChem ID 121513859
InChI Key FJRYQRBEISYVBB-UHFFFAOYSA-N
Smiles O=C1N(C4=CC(F)=CC=C4)NC2=C1C(NCCCC)=NC3=C2C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PQ 69

参考文献是支持产品生物活性的出版物。

Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619 PMID: 25248972

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关键词: PQ 69, PQ 69 supplier, PQ69, Potent, selective, A1, antagonists, receptors, adenosines, inverse, agonists, Adenosine, Receptors, 5351, Tocris Bioscience

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