PR 39 (porcine)

Name: PR 39 (porcine)
Brand: Tocris Bioscience
SKU: 1947

Cat. No. 1947 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1947 has been discontinued.

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说明： IκBα inhibitor

说明书

引用文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for PR 39 (porcine)

PR 39 (porcine) is an antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.

技术数据 for PR 39 (porcine)

分子量	4719.7
公式	C₂₂₉H₃₄₆N₇₀O₄₀
序列	RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP (Modifications: Pro-39 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	139637-11-9
PubChem ID	52949575
InChI Key	SVJCYLXJXIRSHM-IWDHFESKSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PR 39 (porcine)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PR 39 (porcine)

参考文献是支持产品生物活性的出版物。

Gaczynska et al (2003) Proline and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42 8663 PMID: 12873125

Gao et al (2000) Inhibition of ubiquitin-proteasome pathway-mediated IκBα degradation by a naturally occuring antibacterial peptide. J.Clin.Invest. 106 439 PMID: 10930447

Li et al (2000) PR39, a peptide regulator of angiogenesis. Nat.Med. 6 356 PMID: 10613823

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关键词: PR 39, PR 39 supplier, IκB, IκBα, IkappaBalpha, blocks, degradation, inhibitors, inhibits, NF-κB, NF-kappaB, Nf-kB, Transcription, Factors, Nuclear, Factor, Kappa, B, PR39, NF-kB/IkB, 1947, Tocris Bioscience

1 篇 PR 39 (porcine) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PR 39 (porcine) 的部分引用包括：

Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420 PMID: 25828472

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Pathways for PR 39 (porcine)

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.