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PR 619

Cat. No. 4482 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Broad spectrum DUB inhibitor
化学名： 2,6-Diamino-3,5-dithiocyanopyridine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PR 619

PR 619 is a broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.

技术数据 for PR 619

分子量 223.28
公式 C7H5N5S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2645-32-1
PubChem ID 2817763
InChI Key ZXOBLNBVNROVLC-UHFFFAOYSA-N
Smiles NC1=C(SC#N)C=C(SC#N)C(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PR 619

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.23 10

制备储备液 for PR 619

以下数据基于产品分子量 223.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 44.79 mL 223.93 mL 447.87 mL
0.5 mM 8.96 mL 44.79 mL 89.57 mL
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.9 mL 4.48 mL 8.96 mL

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参考文献 for PR 619

参考文献是支持产品生物活性的出版物。

Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401 PMID: 22118674

Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057 PMID: 22565157

If you know of a relevant reference for PR 619, please let us know.

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关键词: PR 619, PR 619 supplier, PR619, inhibitors, DUBs, deubiquitinating, enzymes, deubiquitination, proteasome, inhibits, broad, spectrum, proteases, Deubiquitinating, Enzymes, 4482, Tocris Bioscience

2 篇 PR 619 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PR 619 的部分引用包括：

JoAnn et al (2018) A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep 24 3312-3323.e5 PMID: 30232011

Saldate et al (2018) The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology. J Biol Chem 293 2232 PMID: 29269412

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PR 619 的评论

平均评分: 5 (Based on 1 Review.)

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10 uM PR-619.
By Anonymous on 12/23/2019
分析类型： In Vitro
种属： Rat
细胞系/组织： rat hippocampal neuronal

Cells cultured with 10 uM PR-619

PMID: 29269412
review image