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MPD 2

Cat. No. 8802 Submit a Review Datasheet / COA / SDS
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Description: SARS-CoV-2 Mpro Degrader (PROTAC®)
Chemical Name: 3-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MPD 2

MPD 2 is a SARS-CoV-2 Mpro Degrader (PROTAC®) (DC50 = 296 nM in 293T cells). Mpro degradation is time-dependent and CRBN-mediated. Antiviral in A549-ACE2 cells infected with several SARS-CoV-2 strains (EC50 = 492 nM at delta variant) and against a nirmatrelvir-resistant mutant of SARS-CoV-2, NSP5 E166A (EC50 = 460 nM).

Technical Data for MPD 2

M. Wt 973.13
Formula C51H68N6O13
Storage Store at -20°C
PubChem ID 171663340
InChI Key ZKSDAFLRLHGTNH-DTKLLKMQSA-N
Smiles O=C1[C@@H](CCN1)C[C@H](NC([C@@H](NC([C@@H](NC(OCC2=CC(OCCCCCCOC3=C4C(C(N(C4=O)C5CCC(NC5=O)=O)=O)=CC=C3)=CC=C2)=O)[C@@H](C)OC(C)(C)C)=O)CC6CCCCC6)=O)C([H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MPD 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.31 100

Preparing Stock Solutions for MPD 2

The following data is based on the product molecular weight 973.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.14 mL 10.28 mL
5 mM 0.21 mL 1.03 mL 2.06 mL
10 mM 0.1 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for MPD 2

References are publications that support the biological activity of the product.

Alugubelli et al (2024) Discovery of first-in-class PROTAC Degraders of SARS-CoV-2 main protease. J.Med.Chem. 67 6495 PMID: 38608245

If you know of a relevant reference for MPD 2, please let us know.

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Citations for MPD 2

Citations are publications that use Tocris products.

Currently there are no citations for MPD 2. Do you know of a great paper that uses MPD 2 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia