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Submit ReviewPravastatin sodium salt
说明： HMG-CoA reductase inhibitor
别名： Eptastatin sodium
化学名： (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
纯度： ≥98% (HPLC)
生物活性 for Pravastatin sodium salt
Pravastatin sodium salt is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.
化合物库 for Pravastatin sodium salt
Pravastatin sodium salt is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Pravastatin sodium salt
| 分子量 | 446.51 |
| 公式 | C23H35NaO7 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 81131-70-6 |
| PubChem ID | 16759173 |
| InChI Key | VWBQYTRBTXKKOG-IYNICTALSA-M |
| Smiles | [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pravastatin sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 44.65 | 100 | |
| DMSO | 44.65 | 100 |
制备储备液 for Pravastatin sodium salt
以下数据基于产品分子量 446.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.2 mL | 22.4 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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产品说明书 for Pravastatin sodium salt
参考文献 for Pravastatin sodium salt
参考文献是支持产品生物活性的出版物。
Hamelin and Turgeon (1998) Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 19 26 PMID: 9509899
If you know of a relevant reference for Pravastatin sodium salt, please let us know.
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关键词: Pravastatin sodium salt, Pravastatin sodium salt supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Eptastatin, sodium, Reductase, 2318, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
3 篇 Pravastatin sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pravastatin sodium salt 的部分引用包括：
Ding et al (2016) AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability. Circ Res 119 718 PMID: 27439892
Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Proc Natl Acad Sci U S A 2 1176 PMID: 22202492
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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