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PRIMA-1

Cat. No. 1862 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1862 has been discontinued.

View all p53 products.
说明： Restores mutant p53 activity; induces apoptosis
化学名： 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for PRIMA-1

PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

技术数据 for PRIMA-1

分子量 185.22
公式 C9H15NO3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 5608-24-2
PubChem ID 322968
InChI Key RFBVBRVVOPAAFS-UHFFFAOYSA-N
Smiles O=C1C(CO)(CO)N2CCC1CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PRIMA-1

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书目前不在网上提供。
请联系客户服务。

参考文献 for PRIMA-1

参考文献是支持产品生物活性的出版物。

Bykov et al (2002) Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 8 282 PMID: 11875500

Bykov et al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23 2011 PMID: 12507923

Wang et al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 352 203 PMID: 17113036

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关键词: PRIMA-1, PRIMA-1 supplier, Restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, Bax, PUMA, 1862, Tocris Bioscience

3 篇 PRIMA-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PRIMA-1 的部分引用包括：

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J Neurosci 29 795 PMID: 21315634

Cerchietti et al (2008) Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res 68 3361 PMID: 18451163

Benakanakere et al (2009) Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer 16 85 PMID: 19075036

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PRIMA-1

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.