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Submit ReviewPristimerin
说明： Potent, reversible MAGL inhibitor
化学名： (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid methyl ester
纯度： ≥99% (HPLC)
生物活性 for Pristimerin
Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.
技术数据 for Pristimerin
| 分子量 | 464.64 |
| 公式 | C30H40O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1258-84-0 |
| PubChem ID | 159516 |
| InChI Key | JFACETXYABVHFD-WXPPGMDDSA-N |
| Smiles | O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@](OC)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pristimerin
参考文献 for Pristimerin
参考文献是支持产品生物活性的出版物。
Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734 PMID: 19574249
Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027 PMID: 19096011
King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045 PMID: 19875078
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关键词: Pristimerin, Pristimerin supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors, NF-kB/IkB, 3731, Tocris Bioscience
1 篇 Pristimerin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pristimerin 的部分引用包括：
El-Agamy et al (2018) Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis. Front Pharmacol 9 292 PMID: 29643811
Pristimerin 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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