主页 / 药理学 / Transporters / Multidrug Transporters / Multidrug Transporter Inhibitors / Probenecid

Probenecid

Cat. No. 4107 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MRP and OAT3 inhibitor
化学名： 4-(Dipropylsulfamoyl)benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Probenecid

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC50 = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

化合物库 for Probenecid

Probenecid is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Probenecid

分子量 285.36
公式 C13H19NO4S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 57-66-9
PubChem ID 4911
InChI Key DBABZHXKTCFAPX-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Probenecid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.54 100
ethanol 28.54 100

制备储备液 for Probenecid

以下数据基于产品分子量 285.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Probenecid

参考文献是支持产品生物活性的出版物。

Cunningham et al (1981) Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 6 135 PMID: 7011657

Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608

Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212

Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417

Perwitasai et al (2013) Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 57 475 PMID: 23129053

Murray et al (2021) Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci.Rep. 11 PMID: 34508172

If you know of a relevant reference for Probenecid, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Multidrug Transporter Inhibitors

关键词: Probenecid, Probenecid supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Multidrug, Transporters, Influenza, Viruses, COVID-19, Coronavirus, 4107, Tocris Bioscience

4 篇 Probenecid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Probenecid 的部分引用包括：

Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780

Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979

Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473 PMID: 23878142

Anna et al (2017) The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. Int J Mol Sci 18 PMID: 28726743

您是否知道使用了 Tocris Probenecid 的优秀论文？ 请告知我们.

Probenecid 的评论

目前没有该产品的评论。 Be the first to review Probenecid and earn rewards!

Have you used Probenecid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.