Prosaptide TX14(A)

Cat. No. 5151 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent GPR37 and GPR37L1 agonist

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Prosaptide TX14(A)

Prosaptide TX14(A) is a potent GPR37L1 and GPR37 agonist (EC₅₀ values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.

技术数据 for Prosaptide TX14(A)

分子量	1579.72
公式	C₆₉H₁₁0N₁₆O₂₆
序列	TALIDNNATEEILY (Modification: Ala-2 = D-Ala)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	196391-82-9
PubChem ID	16197909
InChI Key	SMUKRAODILXPSW-SRWCCNGVSA-N
Smiles	[H]N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Prosaptide TX14(A)

溶解性	Soluble to 2 mg/ml in water

产品说明书 for Prosaptide TX14(A)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Prosaptide TX14(A)

参考文献是支持产品生物活性的出版物。

Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 94 4778 PMID: 9114068

Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529 PMID: 23690594

If you know of a relevant reference for Prosaptide TX14(A), please let us know.

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关键词: Prosaptide TX14(A), Prosaptide TX14(A) supplier, Potent, GPR37, GPR37L1, orphan, receptors, agonists, PTX-sensitive, neuroprotective, glioprotective, Orphan, 7-TM, Receptors, 5151, Tocris Bioscience

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