Prostaglandin E₂

Name: Prostaglandin E 2
Brand: Tocris Bioscience
SKU: 2296
Rating: 4 (1 reviews)

Cat. No. 2296 20 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin

别名： PGE₂

化学名： (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

纯度： ≥98% (HPLC)

说明书

引用文献 (20)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Prostaglandin E₂

Prostaglandin E₂ is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E₂ binds with high affinity to EP₁, EP₂, EP₃ and EP₄ receptors (K_d values range between ~ 1 - 10 nM). Prostaglandin E₂ influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E₂ regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.

技术数据 for Prostaglandin E₂

分子量	352.47
公式	C₂₀H₃₂O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	363-24-6
PubChem ID	5280360
InChI Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Smiles	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Prostaglandin E₂

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.25	100
	ethanol	15.86	45

制备储备液 for Prostaglandin E₂

以下数据基于产品分子量 352.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.37 mL
5 mM	0.57 mL	2.84 mL	5.67 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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产品说明书 for Prostaglandin E₂

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Prostaglandin E₂

参考文献是支持产品生物活性的出版物。

Coleman et al (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 46 205 PMID: 7938166

Hata and Breyer (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther. 103 147

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007 PMID: 17581586

Sato et al (2015) SnapShot: Growing organoids from stem cells. Cell. 161 1700 PMID: 26091044

Karthaus et al (2014) Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 159 163 PMID: 25201529

Heffner et al (2018) Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther 26 320 PMID: 29102562

Ke et al (2016) Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer. Tumour Biol. 37 12203 PMID: 27230680

If you know of a relevant reference for Prostaglandin E₂, please let us know.

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关键词: Prostaglandin E2, Prostaglandin E2 supplier, endogenous, prostanoid, EP1, EP2, EP3, EP4, Receptors, prostaglandins, prostacyclins, eicosanoids, ProstaglandinE2, stem, cells, e2, PGE2, hematopoietic, haematopoietic, HSC, Prostanoid, Stem, Cell, Signaling, Proliferation, Organoids, Viral, Transduction, Enhancers, Hematopoietic, Cells, 2296, Tocris Bioscience

20 篇 Prostaglandin E₂ 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Prostaglandin E₂ 的部分引用包括：

Post et al (2020) Snake venom gland organoids. Cell 180 233 PMID: 31978343

Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460 PMID: 25949900

Anneken et al (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Respir Res 8 58 PMID: 23179355

Langdale et al (2017) Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. Am J Physiol Renal Physiol 313 F657 PMID: 28615244

Colomer et al (2019) IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell 75 669 PMID: 31302002

Ye et al (2018) Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7 749 PMID: 29700097

Zhu (2018) Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients. Oncotarget 9 982 PMID: 29416671

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862

Weeber et al (2015) Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Cell 112 13308 PMID: 26460009

Boj et al (2015) Organoid models of human and mouse ductal pancreatic cancer. Sci Signal 160 324 PMID: 25557080

Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. J Neuroimmune Pharmacol 5 ra26 PMID: 22472648

He et al (2022) Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell 29 1333 PMID: 36002022

Drost et al (2016) Organoid culture systems for prostate epithelial and cancer tissue. Proc Natl Acad Sci U S A 11 347 PMID: 26797458

Sherman et al (2018) A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity. Front Immunol 9 857 PMID: 29740450

Senger et al (2018) Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). Cell Mol Gastroenterol Hepatol 5 549 PMID: 29930978

Somerville et al (2018) TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep 25 1741 PMID: 30428345

Sachamitr et al (2018) Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset. Front Immunol 8 1935 PMID: 29358940

Al-Taei et al (2017) Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology 6 e1268308 PMID: 28344879

Roe et al (2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell 170 875 PMID: 28757253

Ma et al (2017) Organoid culture of human prostate cancer cell lines LNCaP and C4-2B. Am J Clin Exp Urol 5 25 PMID: 29181435

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